New Celtic attacking duo Kasper Hogh and Camilo Duran scored 10 goals between them in the Champions League proper last term.
Both have made promising starts since their big-money summer arrivals from Bodo/Glimt and Qarabag respectively and will hope to be the difference.
Although Arne Engels and Daizen Maeda have departed, Haissem Hassan and Mika Baur have also joined for chunky fees and feature in Celtic's squad for this two-legged affair.
For O'Neill, though, this tie marks another surreal moment in a whirlwind year.
"I didn't think last September or October that I'd be sitting here now thinking about a Champions League game," he said. "If I was, I'd certainly be watching it on TV."
It has been more than 20 years since O'Neill managed a Champions League match, or even a qualifier. His record as a manager in the competition stands at six wins from 18 matches.
In three qualification attempts for the competition, he has been successful twice. There was also a Uefa Cup final appearance in 2003 and he made it to the quarter-finals the following year.
A two-legged play-off against LASK stands between an older and wiser O'Neill and a return to the pinnacle of club football, where he could flex his European pedigree.
The Northern Irishman refused to put a ceiling on what is possible for Celtic at Champions League level, using the club's 1967 European Cup triumph as a benchmark.
"I've said all along, I think the bar was set here way back in 1967," he added. "And from then on, I believe that Celtic should be aspiring to that.
"We may never, ever, ever get there. And obviously with the way that the financial market has moved in football, it's getting more and more difficult for a team from Scotland.
"But that aside, you should still be aspiring to it. That's what we want to try and do. We may never get there, but this is the bar that's been set down.
"The football club won the European Cup, and really, that's what we should be trying to do. We will make an all-out effort to try and make it."